High efficiency and sensitivity magnetic induction bio-sensor

Zu-Yin Deng^1*, Nien-Tsu Chiang², Chiu-Hsien Wu^1,2

¹Department of physics, National Chung-Hsing University, Taichung, Taiwan
²institute of Nanoscience, National Chung-Hsing University, Taichung, Taiwan

* Presenter:Zu-Yin Deng, email:g103054104@mail.nchu.edu.tw

In this study, a magnetization biosensor for Bovine serum albumin antigen was built with a stacked nanoparticles (npls) chip. Interleaved stacking gold and iron-oxide npl structures could be vibrated in the external AC magnetic field. For this reason, magnetic moment was flipped by the ptl vibration. With the protein structures were coated on, the frequency of magnetic moment flipping was delayed by viscosity of antibodies and (BSA) antigens. The antigen concentrations was reflected by magnetization intensity decayed. The detect limit of antigen concentration was 15 μg/mL. And the immune response time was 10 - 15 seconds. It was faster than magnetic liquid regent.
Gold npls on the top surface provide high biocompatibility. In the same time, free electrons were excited by light (532nm). This electric field of surface enhanced the signals for 10%. This detection method was a sensitive, immediate and convenient method for bio-detector.

Keywords: AC magnetic induction, Chip bio-sensor